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Conjugation of a Scintillator Complex and Gold Nanorods for Dual-Modal Image-Guided Photothermal and X‑ray-Induced Photodynamic Therapy of Tumors
journal contribution
posted on 2020-03-09, 15:37 authored by Li Luo, Wenjing Sun, Yushuo Feng, Ruixue Qin, Jinghui Zhang, Dandan Ding, Tianhang Shi, Xiangmei Liu, Xiaoyuan Chen, Hongmin ChenLight-mediated
therapy has many unique merits but monotherapy strategies rarely completely
inhibit tumor growth because resistance often develops. Combination
therapy is a promising strategy in oncology and has demonstrated superior
safety and efficacy over monotherapy. Here, we conjugated a scintillator
complex and gold nanorod nanosensitizer for dual-modal image-guided
photothermal and X-ray-induced photodynamic therapy (PDT). Lanthanide
complexes were successfully conjugated and offer excellent X-ray-excited
optical luminescence for PDT effects. The strong near-infrared (NIR)
light and X-ray absorption abilities of gold nanorods make the nanosensitizer
function as both a photothermal agent for photothermal therapy and
a radiosensitizer for enhanced radiotherapy. The studies in vitro
and in vivo demonstrated that the nanosensitizer offers good dual-modal
imaging capability and significantly suppresses tumor progression
under NIR light and X-ray irradiation. This work shows the great potential
of conjugating scintillator lanthanide complexes and gold nanosensitizers
for multimodal image-guided therapy of deep-seated tumors.
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Keywords
gold nanorod nanosensitizergold nanorodsgold nanosensitizersmonotherapy strategiesmultimodal image-guided therapyphotothermal therapyLanthanide complexesCombination therapystrategytumor progressionPDT effectsdual-modal imaging capabilityX-ray-induced photodynamic therapynanosensitizer functionGold NanorodsX-ray irradiationphotothermal agentX-ray absorption abilitiesscintillator lanthanide complexesScintillator Complexdual-modal image-guided photothermalDual-Modal Image-Guided Photothermaltumor growthNIR lightTumors Light-mediated therapy
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