am7b03906_si_001.pdf (730.91 kB)
Conjugated Polymers Act Synergistically with Antibiotics to Combat Bacterial Drug Resistance
journal contribution
posted on 2017-05-18, 00:00 authored by Jingxiao Tian, Jiangyan Zhang, Jiangtao Yang, Lingyun Du, Hao Geng, Yongqiang ChengThe
emergence of drug-resistant bacteria severely challenges the antimicrobial
agents and antibacterial strategy. Here, we demonstrate a novel, simple,
and highly efficient combination therapy strategy by direct combinations of cationic conjugated
polymers (CCPs) with polypeptide antibiotics against Gram-negative
and Gram-positive bacteria based on a synergistic antibacterial effect.
The combination therapy method enhances the antibacterial efficacy
with a significantly reduced antibiotic dosage. Also, the highly efficient
and synergistic killing of drug-resistant bacteria is realized. Using
combinations of CCPs and antibiotics to show increased antibacterial
activity, this strategy will provide a much wider scope of the discovery
of efficient antibacterial systems than that of antibiotic–antibiotic
combinations. The proposed combination therapy method provides a universal
and powerful platform for the treatment of pathogens, in particular,
the drug-resistant bacteria, and also opens a new way for the development
of efficient antibacterial systems.