Concise and Efficient Synthesis of
4-Fluoro-1H-pyrrolo[2,3-b]pyridine

Thibault, Carl; L'Heureux, Alexandre; Bhide, Rajeev S.; Ruel, Réjean

doi:10.1021/ol036030z.s002

ol036030z_si_002.pdf (61.93 kB)

Concise and Efficient Synthesis of 4-Fluoro-1H-pyrrolo[2,3-b]pyridine

journal contribution

posted on 2003-12-25, 00:00 authored by Carl Thibault, Alexandre L'Heureux, Rajeev S. Bhide, Réjean Ruel

Two routes describing the preparation of 4-fluoro-1H-pyrrolo[2,3-b]pyridine (4a) from 1H-pyrrolo[2,3-b]pyridine N-oxide (1) are presented. Regioselective fluorination was achieved using either the Balz−Schiemann reaction or lithium−halogen exchange.