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Complexation of Iron and Copper in Ambient Particulate Matter and Its Effect on the Oxidative Potential Measured in a Surrogate Lung Fluid
journal contribution
posted on 2018-12-27, 00:00 authored by Jinlai Wei, Haoran Yu, Yixiang Wang, Vishal VermaWe
investigated the complexation state of atmospheric iron and
copper and its impact on the oxidative potential (OP) of ambient PM2.5 (PM, particulate matter). A novel fractionation scheme
was developed to segregate three different fractions of Fe and Cu
present in ambient PM2.5: (i) complexed with hydrophobic
organic compounds, (ii) complexed with hydrophilic organic compounds,
and (iii) free or inorganic metal fraction. A solid phase extraction
(C-18) column was used to separate these fractions. The fractionation
scheme applied to the ambient PM2.5 samples collected from
an urban site showed that up to 70–90% of water-soluble Fe
and Cu were complexed with the organic compounds. The capability of
the complexes of Fe(II) and Cu(II) with Suwanee river fulvic acid
(SRFA), a proxy for the atmospheric organic compounds, to generate
reactive oxygen species (ROS) (·OH and H2O2) in a surrogate lung fluid (SLF) was measured. The complex of Fe–SRFA
showed a strong synergistic effect in the generation of ·OH in
SLF, while that of Cu–SRFA showed an additive effect. Overall,
our results indicate that organic complexation of the metals in ambient
PM could significantly alter their OP and needs to be considered while
assessing their health impacts.
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metal fractionhealth impactsphase extractionlung fluidcompoundSuwanee river fulvic acidOHnovel fractionation schemeOPROSAmbient Particulate Matterreactive oxygen speciesFeadditive effectambient PM 2.5 samplesH 2 O 2Cuambient PM 2.5fractionation schemecomplexedSRFASLFcomplexation stateambient PMSurrogate Lung Fluid
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