ol302680m_si_002.cif (19.06 kB)
Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts
dataset
posted on 2012-11-02, 00:00 authored by Jonathan K. Lam, Yvonne Schmidt, Christopher D. VanderwalThe intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.