ol7b02117_si_001.pdf (7.57 MB)
Cobalt-Catalyzed Silylcarbonylation of Unactivated Secondary Alkyl Tosylates at Low Pressure
journal contribution
posted on 2017-08-11, 18:35 authored by Joan E. Roque Peña, Erik J. AlexanianA catalytic
preparation of silyl enol ethers from unactivated secondary
alkyl tosylates is reported. An inexpensive cobalt catalyst is used
under mild conditions with low pressures of carbon monoxide. Nucleophilic,
anionic cobalt carbonyls facilitate the catalytic activation of a
range of alkyl tosylates. The silylcarbonylation offers a practical
approach to synthetically valuable silyl enol ethers from simple starting
materials.