ol0c01557_si_001.pdf (5.61 MB)
Cobalt-Bisoxazoline-Catalyzed Enantioselective Cross-Coupling of α‑Bromo Esters with Alkenyl Grignard Reagents
journal contribution
posted on 2020-05-21, 16:41 authored by Yun Zhou, Lifeng Wang, Gucheng Yuan, Shikuo Liu, Xiao Sun, Chaonan Yuan, Yuxiong Yang, Qinghua Bian, Min Wang, Jiangchun ZhongThe first catalytic asymmetric Kumada
cross-coupling of organic
halides with alkenyl Grignard reagents has been developed. The reaction
was promoted by the cobalt-bisoxazoline catalyst and afforded various
α-alkyl-β,γ-unsaturated esters with excellent enantioselectivities
and moderate to good yields (≤95% ee and ≤82% yields).
The formal synthesis of the California red scale pheromone using this
method was investigated, and radical clock experiments were performed.