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Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials
journal contribution
posted on 2020-05-22, 15:37 authored by Wei Ji, Chengqian Yuan, Priyadarshi Chakraborty, Pandeeswar Makam, Santu Bera, Sigal Rencus-Lazar, Junbai Li, Xuehai Yan, Ehud GazitConformational
transition of proteins and peptides into highly
stable, β-sheet-rich structures is observed in many amyloid-associated
neurodegenerative disorders, yet the precise mechanism of amyloid
formation at the molecular level remains poorly understood due to
the complex molecular structures. Short peptides provide simplified
models for studying the molecular basis of the assembly mechanism
that governs β-sheet fibrillation processes underlying the formation
and inhibition of amyloid-like structures. Herein, we report a supramolecular
coassembly strategy for the inhibition and transformation of stable
β-sheet-rich amyloid-derived dipeptide self-assemblies into
adaptable secondary structural fibrillar assemblies by mixing with
bipyridine derivatives. The interplay between the type and mixing
ratio of bipyridine derivatives allowed the variable coassembly process
with stimuli-responsive functional properties, studied by various
experimental characterizations and computational methods. Furthermore,
the resulting coassemblies showed functional redox- and photoresponsive
properties, making them promising candidates for controllable drug
release and fluorescent imprint. This work presents a coassembly strategy
not only to explore the mechanism of amyloid-like structure formation
and inhibition at the molecular level but also to manipulate amyloid-like
structures into responsive supramolecular coassemblies for material
science and biotechnology applications.
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Keywords
amyloid-like structure formationDipeptide Amyloid-Like Structuresamyloid-like structuresmechanismsupramolecular coassembly strategyStimuli-Responsive Supramolecular Materials Conformational transitionβ- sheet fibrillation processesβ- sheet-rich amyloid-derived dipeptide self-assembliesinhibitionamyloid-associated neurodegenerative disorderscoassemblieβ- sheet-rich structuresbipyridine derivatives
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