Chiral Phosphine Oxide–Sc(OTf)3 Complex Catalyzed Enantioselective Bromoaminocyclization of 2‑Benzofuranylmethyl N‑Tosylcarbamates. Approach to a Novel Class of Optically Active Spiro Compounds

2015-12-04T00:00:00Z (GMT) by Zequan Li Yian Shi
An efficient enantioselective bromoaminocyclization of 2-benzofuranylmethyl N-tosylcarbamates catalyzed by a chiral phosphine oxide–Sc­(OTf)3 complex is described. A wide variety of optically active spiro benzofuran oxazolidinones can be obtained with high enantioselectivities.