Catalytic and Highly Efficient
1,4-Addition of Terminal Alkynes to
Conjugated Enones by
[RuCl2(p-cymene)]2/Pyrrolidine

Chang, Sukbok; Na, Youngim; Choi, Eunjung; Kim, Sunggak

doi:10.1021/ol016047m.s001

ol016047m_si_001.pdf (43.88 kB)

Catalytic and Highly Efficient 1,4-Addition of Terminal Alkynes to Conjugated Enones by [RuCl₂(p-cymene)]₂/Pyrrolidine

journal contribution

posted on 2001-06-01, 00:00 authored by Sukbok Chang, Youngim Na, Eunjung Choi, Sunggak Kim

A wide range of terminal alkynes was added to conjugated enones in a 1,4-fashion by a ruthenium catalyst in the presence of catalytic amounts of an amine base, and the corresponding γ,δ-alkynyl ketones were obtained in good to excellent yields.

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fashion Catalytic presence Efficient cymene amine base Terminal Alkynes ketone Pyrrolidine alkynyl ruthenium catalyst yield Conjugated Enones RuCl 2 enone terminal alkynes

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Catalytic and Highly Efficient 1,4-Addition of Terminal Alkynes to Conjugated Enones by [RuCl2(p-cymene)]2/Pyrrolidine