ol9b02617_si_001.pdf (11.14 MB)
Catalytic Tandem Friedel–Crafts Alkylation/C4–C3 Ring-Contraction Reaction: An Efficient Route for the Synthesis of Indolyl Cyclopropanecarbaldehydes and Ketones
journal contribution
posted on 2019-09-05, 20:36 authored by Francesca Turnu, Alberto Luridiana, Andrea Cocco, Stefania Porcu, Angelo Frongia, Giorgia Sarais, Francesco SecciA general
strategy for the synthesis of indolyl cyclopropanecarbaldehydes
and ketones via a Brønsted acid-catalyzed indole nucleophilic
addition/ring-contraction reaction sequence has been exploited. The
procedure leads to a wide panel of cyclopropyl carbonyl compounds
in generally high yields with a broad substrate scope.