Catalytic Tandem Friedel–Crafts Alkylation/C4–C3 Ring-Contraction Reaction: An Efficient Route for the Synthesis of Indolyl Cyclopropanecarbaldehydes and Ketones
2019-09-05T20:36:24Z (GMT)
by
A general
strategy for the synthesis of indolyl cyclopropanecarbaldehydes
and ketones via a Brønsted acid-catalyzed indole nucleophilic
addition/ring-contraction reaction sequence has been exploited. The
procedure leads to a wide panel of cyclopropyl carbonyl compounds
in generally high yields with a broad substrate scope.
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CC BY-NC 4.0