Catalytic Divergent Synthesis of 3<i>H</i> or 1<i>H</i> Pyrroles by [3 + 2] Cyclization of Allenoates with Activated Isocyanides

2015-01-21T00:00:00Z (GMT) by Jia-Yu Liao Pan-Lin Shao Yu Zhao
The cyclization of allenoates with activated isocyanides was reported for the first time. While Ag catalysis led to an unprecedented enantioselective synthesis of 3<i>H</i> pyrroles, a simple procedure using PPh<sub>3</sub> produced a wide range of polysubstituted 1<i>H</i> pyrroles with high efficiency.