ja511895q_si_003.pdf (7.65 MB)
Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3 + 2] Cyclization of Allenoates with Activated Isocyanides
journal contribution
posted on 2015-01-21, 00:00 authored by Jia-Yu Liao, Pan-Lin Shao, Yu ZhaoThe
cyclization of allenoates with activated isocyanides was reported
for the first time. While Ag catalysis led to an unprecedented enantioselective
synthesis of 3H pyrroles, a simple procedure using
PPh3 produced a wide range of polysubstituted 1H pyrroles with high efficiency.