ol303469a_si_003.pdf (6 MB)
Catalytic Asymmetric Synthesis of Cyclic Sulfamides from Conjugated Dienes
journal contribution
posted on 2013-02-15, 00:00 authored by Richard G. Cornwall, Baoguo Zhao, Yian ShiThis paper describes the catalytic asymmetric diamination of alkyl dienes using N,N′-di-tert-butylthiadiaziridine 1,1-dioxide in the presence of Pd(0) and a chiral phosphoramidite ligand to give cyclic sulfamides in high yield and high ee. The diamination is also amenable to gram scale.