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Catalytic Asymmetric Mannich Type Reaction with Tri-/Difluoro- or Trichloroacetaldimine Precursors

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journal contribution
posted on 2018-11-08, 00:00 authored by Yang’en You, Sanzhong Luo
A highly efficient catalytic asymmetric Mannich type reaction of CF3-, CF2H-, or CCl3-acetaldimine precursors by a chiral primary amine is presented. This protocol provides facile access to chiral CF3-, CF2H-, or trichloroethyl amines in excellent yields and high enantioselectivity (up to 99% yield, up to >99% ee).

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