ol8b03083_si_001.pdf (11.78 MB)
Catalytic Asymmetric Mannich Type Reaction with Tri-/Difluoro- or Trichloroacetaldimine Precursors
journal contribution
posted on 2018-11-08, 00:00 authored by Yang’en You, Sanzhong LuoA highly
efficient catalytic asymmetric Mannich type reaction of
CF3-, CF2H-, or CCl3-acetaldimine
precursors by a chiral primary amine is presented. This protocol provides
facile access to chiral CF3-, CF2H-, or trichloroethyl
amines in excellent yields and high enantioselectivity (up to 99%
yield, up to >99% ee).