Catalyst-Free and Selective C–N Bond Functionalization: Stereospecific Three-Component Coupling of Amines, Dichloromethane, and >P(O)H Species Affording α‑Aminophosphorus Compounds

Catalyst-free and selective C–N bond functionalization has been achieved through three-component coupling of amines, dihalomethane, and >P­(O)H species. This reaction takes place stereospecifically with retention of configuration at phosphorus, which can produce various new optically active phosphorus analogues of α-amino acids.