ol7b01851_si_004.cif (1.03 MB)
Catalyst-Enabled Scaffold Diversity: Highly Chemo- and Stereoselective Synthesis of Tricyclic Ketals and Triarylmethanes
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posted on 2017-07-14, 17:20 authored by Jia-Yu Liao, Qijian Ni, Yu ZhaoThe first catalytic
cascade reaction of activated isocyanides with para-quinone methide-aryl esters is presented. Catalyst-enabled
divergent pathways have also been achieved to deliver skeletally diverse
products. While Ag catalysis leads to an unprecedented highly diastereoselective
synthesis of tricyclic ketals, a simple procedure employing Cu catalysis
produces oxazole-containing triarylmethanes in high efficiency through
an unexpected C–C bond cleavage.
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Catalyst-enabledChemoTricyclic Ketalscascade reactionStereoselective Synthesisoxazole-containing triarylmethanesskeletallyquinone methide-aryl estersTriarylmethaneCu catalysispathwaybondparatricyclic ketalsCatalyst-Enabled Scaffold Diversitydiastereoselective synthesisefficiencyisocyanidecleavageAg catalysisprocedure
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