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Cascade Cyclizations and Couplings Involving Nickel Enolates

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posted on 2003-10-08, 00:00 authored by Gireesh M. Mahandru, Andy R. L. Skauge, Sanjoy K. Chowdhury, Kande K. D. Amarasinghe, Mary Jane Heeg, John Montgomery
A new strategy for effecting cascade cyclization processes using nickel enolates has been developed. Nickel enolates may be cleanly generated by the oxidative cyclization of an enal and alkyne with Ni(0), and the resulting enolate may be functionalized by a variety of alkylation processes. Partially and fully intramolecular versions of the process allow the rapid synthesis of complex polycyclics from simple achiral, acyclic precursors.

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