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Carbon Dots/Prussian Blue Satellite/Core Nanocomposites for Optical Imaging and Photothermal Therapy
journal contribution
posted on 2017-12-18, 00:00 authored by Xinyi Peng, Rui Wang, Tingjian Wang, Wanning Yang, Hao Wang, Wei Gu, Ling YeIntegration
of optical imaging modality with photothermal therapy (PTT) for simultaneously
providing oncotherapy and bioimaging enables an optimized therapeutic
efficacy and higher treatment accuracy and therefore has emerged as
a prospective cancer treatment. However, it remains challenging to
develop biocompatible PTT nanoagents capable of imaging, monitoring,
and diagnosis. Carbon dots (CDs) possess unique photoluminescent (PL)
properties and intrinsic biocompatibility; while Prussian blue nanoparticles
(PBNPs) are nontoxic with efficient photothermal conversion capacity
for PTT. Herein, a simple, cost-effective, and environmentally benign
method was developed to strategically fabricate CD-decorated PBNP
(CDs/PBNP) nanocomposites with satellite/core structure. The CDs/PBNPs
possess distinct green PL emission and near-infrared photoabsorption
with high efficiency and photothermal stability. In vitro and in vivo
toxicity tests prove the biocompatibility of the CDs/PBNPs. Moreover,
the applicability of CDs/PBNPs as nanotheranostic agents was tested,
which suggests that CDs/PBNPs possess promising imaging and effective
tumor ablation properties.
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Keywords
vivo toxicity teststreatment accuracyPhotothermal Therapy Integrationnear-infrared photoabsorptioncarbon dotsbiocompatible PTT nanoagentsCD-decorated PBNPcancer treatmentphotothermal therapyimaging modalityPL emissiontumor ablation propertiesphotothermal stabilityphotothermal conversion capacitynanotheranostic agentsOptical Imaging
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