Reactive oxygen and
nitrogen species (RONS), especially reactive
nitrogen species (RNS) are intermediate products during incidence
of nervous system diseases, showing continuous damage for traumatic
brain injury (TBI). Here, we developed a carbogenic nanozyme, which
shows an antioxidant activity 12 times higher than ascorbic acid (AA)
and behaves as multienzyme mimetics. Importantly, the nanozyme exhibits
an ultrahigh scavenging efficiency (∼16 times higher than AA)
toward highly active RNS, such as •NO and ONOO– as well as traditional reactive oxygen species (ROS)
including O2•–, H2O2, and •OH. In vitro experiments show that
neuron cells injured by H2O2 or lipopolysaccharide
can be significantly recovered after carbogenic nanozyme treatment
via scavenging all kinds of RONS. Moreover, the carbogenic nanozyme
can serve as various enzyme mimetics and eliminate the harmful peroxide
and glutathione disulfide from injured mice, demonstrating its potential
as a therapeutic for acute TBI.