bc0c00172_si_001.pdf (4.04 MB)
Cancer Photothermal Therapy with ICG-Conjugated Gold Nanoclusters
journal contribution
posted on 2020-05-11, 18:35 authored by Xingya Jiang, Bujie Du, Yingyu Huang, Mengxiao Yu, Jie ZhengThe coming era of
precision nanomedicine demands engineered nanoparticles
that can be readily translated into the clinic, like that of molecular
agents, without being hindered by intrinsic size heterogeneity and
long-term body retention. Herein we report that conjugation of indocyanine
green (ICG), an FDA-approved near-infrared (NIR) dye, onto an atomically
precise glutathione-coated Au25 (GS-Au25) nanocluster led to a molecular-like
photothermal nanoparticle (ICG4–GS-Au25) with significantly
enhanced ICG photostability and tumor targeting. Under weak NIR light
irradiation conditions, free ICG failed to suppress tumor growth but
the original tumors were completely eradicated with ICG4–GS-Au25. In the meantime,
“off-target” ICG4–GS-Au25 was effectively
cleared out from the body like small-molecule drugs after glutathione-mediated
biotransformation in the liver. These findings highlight the merits
of molecular-like nanomedicines, offering a new pathway to meet FDA’s
criteria for the clinical translation of nanomedicines.
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GS-Aucancer Photothermal Therapysize heterogeneitymolecular-like nanomedicinessmall-molecule drugsNIR light irradiation conditionsICG-Conjugated Gold Nanoclustersprecision nanomedicine demandsbody retentionmolecular-like photothermal nanoparticletumor growthglutathione-mediated biotransformationICG photostabilityFDA-approved near-infrared
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