np6b00203_si_001.pdf (2.44 MB)
Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata
journal contribution
posted on 2016-07-05, 16:50 authored by Sarath
P. Gunasekera, Lorelie Imperial, Christiana Garst, Ranjala Ratnayake, Long H. Dang, Valerie J. Paul, Hendrik LueschThe isolation, structure determination,
and biological activities
of a new linear pentapeptide, caldoramide (5), from the
marine cyanobacterium Caldora penicillata from Florida
are described. Caldoramide (5) has structural similarities
to belamide A (4), dolastatin 10 (1), and
dolastatin 15 (2). We profiled caldoramide against parental
HCT116 colorectal cancer cells and isogenic cells lacking oncogenic
KRAS or hypoxia-inducible factors 1α (HIF-1α) and 2α
(HIF-2α). Caldoramide (5) showed differential cytotoxicity
for cells containing both oncogenic KRAS and HIF over the corresponding
knockout cells. LCMS dereplication indicated the presence of caldoramide
(5) in a subset of C. penicillata samples.