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Bound Phenolics Ensure the Antihyperglycemic Effect of Rice Bran Dietary Fiber in db/db Mice via Activating the Insulin Signaling Pathway in Skeletal Muscle and Altering Gut Microbiota
journal contribution
posted on 2020-04-01, 15:42 authored by Xinwen Zhang, Lihong Dong, Xuchao Jia, Lei Liu, Jianwei Chi, Fei Huang, Qin Ma, Mingwei Zhang, Ruifen ZhangWhole-grain
dietary fiber intake is beneficial in the prevention
of metabolic syndrome. Considering rich in bound phenolics being a
special characteristic of whole-grain dietary fiber, the aim of this
study was to evaluate the effects of the presence or absence of bound
phenolics in rice bran dietary fiber (RBDF) on regulating glucose
metabolism in diabetic db/db mice.
In comparison to phenolics-removed RBDF (PR-RBDF) intervention without
an antihyperglycemic effect, RBDF and formulated RBDF (F-RBDF, obtained
by mixing PR-RBDF and hydrolyzed-bound phenolics) significantly reduced
fasting blood glucose levels after 1 and 5 weeks of interventions,
respectively. The presence of bound phenolics interventions could
activate the IRS1/AKT/GLUT4 insulin signaling pathway in skeletal
muscle and alter gut microbiota by modulating gut microbiota dysbiosis
and enriching the butyric-acid-producing bacteria genera of the families
Lachnospiraceae and Ruminococcaceae, thus leading to the reduction
of blood glucose levels. These findings indicate that bound phenolics
ensure the antihyperglycemic effect of RBDF.