jo3011717_si_003.cif (20.81 kB)
Bis(perfluoroalkyl) Phosphino-Oxazoline: A Modular, Stable, Strongly π‑Accepting Ligand for Asymmetric Catalysis
dataset
posted on 2012-09-21, 00:00 authored by Zongjian Hu, Yuguang Li, Kai Liu, Qilong ShenA new class of stable, strongly π-accepting and
modular bis(perfluoroalkyl)-phosphine-oxazoline
ligands (FOX) as CO mimics was prepared. It was demonstrated that
these ligands, when coordinated to palladium catalysts, promote the
asymmetric alkylation of monosubstituted allyl substrates with excellent
regio- and enantioselectivity. Solid and solution structure analysis
of the FOX-ligated Pd-allyl intermediate reveals that the combination
of relative steric and strong trans influences presented
by the P(CF3)2 moiety gave rise to the excellent
selectivity.
