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Biomineralization-Driven Ion Gate in TiO2 Nanochannel Arrays for Cell H2S Sensing
journal contribution
posted on 2019-10-10, 14:04 authored by Junli Guo, Lingling Yang, Huijie Xu, Chenxi Zhao, Zhenqing Dai, Zhida Gao, Yanyan SongThe level of hydrogen
sulfide in the brain and vasculature has
long been associated with human health and diseases. Hence, simple
and robust analytical tools allowing determination of hydrogen sulfide
levels are highly desirable. In this work, a biomineralization-driven
ion gate in TiO2 nanochannel arrays for H2S
sensing was designed and developed. The formed CuS precipitation decreased
the transmembrane current in the presence of bovine serum albumin
used as biological mineralizer. Label-free assay for sensing of intracellular
S2– was achieved based on changes in ionic current
with a detection limit of 56 MCF-7 cells. More importantly, the proposed
sensing strategy was promising for reusable application through dissolution
of CuS in an acidic media (pH = 1).
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presencedissolutionstrategyTiO 2 nanochannel arraysmineralizervasculatureBiomineralization-Driven Ion GateapplicationCuS precipitationtransmembraneTiO 2 Nanochannel Arraysdetection limitpH56 MCF -7 cellshydrogen sulfide levelstoolintracellulardeterminationbiomineralization-driven ion gateH 2 Sacidic mediaCell H 2 SLabel-free assayhydrogen sulfideserum albumin
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