posted on 2020-06-03, 22:29authored byBianyun Cai, Peijie Tan, Nan Jiang, Zhijun Guo, Birol Ay, Shujun Li, Yi Hou, Yubao Li, Yanjun You, Li Zhang, Songsong Zhu
Bioinspired
by the morphology of osteoclast-resorbed bone surfaces,
we prepared a calcium-doped titanium phosphate (Ca-TiP) coating, which
consists of a nanofibrous network, on titanium (Ti) substrate via
a simple two-step hydrothermal method, trying to mimic natural bone
compositionally and microstructurally. The in vitro studies show that the Ca-TiP coating with synergistic features of
nanofibrous biomimetic topography and surface chemistry could elicit
intensively osteogenic behavior and responses including enhanced cell
adhesion, spreading, and proliferation as well as alkaline phosphatase
(ALP) activity and up-regulated expression of bone-related genes,
which inevitably benefit the formation of new bone and the quality
of osseointegration. When the two control groups are compared in vivo, the significantly improved new bone formation in
the early stage and the much stronger interfacial bonding with the
surrounding bone for Ca-TiP coating suggest that Ca-TiP coating modified
Ti implants hold great potential for orthopedic and dental applications.