am8b18095_si_003.avi (546.14 kB)
Bioinspired Concentric-Cylindrical Multilayered Scaffolds with Controllable Architectures: Facile Preparation and Biological Applications
media
posted on 2018-11-26, 00:00 authored by Xiaopeng Cheng, Honghui Shi, Zhaofei Wang, Guoqiang Zheng, Pingping Liu, Kun Dai, Chuntai Liu, Changyu ShenMultilayered
objects are the most important and interesting structures
in nature, exhibiting multiple functionalities. Inspired by the excellent
structural–functional characteristics of nature creatures,
concentric-cylindrical multilayered scaffolds were prepared by a combination
of melt extrusion and leaching, in which well-defined alternating
microlayer/gap is assembled. Furthermore, the macroscopic shape, internal
structure, and surface topography of such a multilayered scaffold
can be elaborately prepared by a simple physical process. The whole
process has low cost, is efficient, and is environmentally friendly.
Furthermore, such multilayered scaffolds show some interesting applications,
e.g., lipophilic/hydrophilic drugs delivery and cell self-seeding.
Considering the facile preparation process and versatile applications,
this study will open up a new pathway to fabricate scaffolds with
controllable architectures and expand their biodegradable polymer
applications.