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Biofunctional Silk Kirigami With Engineered Properties
journal contribution
posted on 2020-03-05, 15:54 authored by Sayantan Pradhan, Leonardo Ventura, Francesca Agostinacchio, Meng Xu, Ettore Barbieri, Antonella Motta, Nicola M. Pugno, Vamsi K. YadavalliThe fabrication of
multifunctional materials that interface with living environments
is a problem of great interest. A variety of structural design concepts
have been integrated with functional materials to form biodevices
and surfaces for health monitoring. In particular, approaches based
on kirigami-inspired cuts can engineer flexibility in materials through
the creation of patterned defects. Here, the fabrication of a biodegradable
and biofunctional “silk kirigami” material is demonstrated.
Mechanically flexible, free-standing, optically transparent, large-area
biomaterial sheets with precisely defined and computationally designed
microscale cuts can be formed using a single-step photolithographic
process. Using modeling techniques, it is shown how cuts can generate
remarkable “self-shielding” leading to engineered elastic
behavior and deformation. As composites with conducting polymers,
flexible, intrinsically electroactive sheets can be formed. Importantly,
the silk kirigami sheets are biocompatible, can serve as substrates
for cell culture, and be proteolytically resorbed. The unique properties
of silk kirigami suggest a host of applications as transient, “green”,
functional biointerfaces, and flexible bioelectronics.
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electroactive sheetsmicroscale cutsmodeling techniquesphotolithographic processform biodevicesbiomaterial sheetssilk kirigami sheetssilk kirigamimultifunctional materialsdesign conceptsBiofunctional Silk Kirigamifabricationproteolytically resorbedcell culturehealth monitoringkirigami-inspired cutsEngineered Properties
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