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Biodegradable Scaffolds for Urethra Tissue Engineering Based on 3D Printing
journal contribution
posted on 2020-03-18, 16:33 authored by Yifan Xu, Qinghua Meng, Xin Jin, Feng Liu, Jianjun YuTissue
engineering scaffolds are used to repair urethra universally,
whereas few of those methods could fit the specific shape of the patient’s
lesion. Here a selection of biodegradable polymers were made, and
then an economic, biodegradable, modified material PLGA/PCL/TEC 70:30:6
with good biocompatibility and mechanical properties was prepared.
A method for customized tissue engineering scaffolds based on 3D printing
technology was established. Based on medical image data, three-dimensional
template models were built up with a certain process for 3D printing.
Customized scaffolds can be prepared by coating the printed template
with modified material and removing the inner template. L929 was selected
as the cell model to observe cytotoxicity and cell adhesion on materials’
films. The prepared scaffolds were assessed by scanning electron microscopy
and degradation in vitro to verify the feasibility as urethra scaffolds
for tissue engineering.
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Biodegradable Scaffoldstissue engineeringimage datarepair urethrascanning electron microscopyl 9293 D printing technologyurethra scaffoldstissue engineering scaffoldscell adhesionCustomized scaffoldsmethod3 D printingmaterialcell modeltemplate modelsPLGA3 D Printing Tissue engineering scaffoldsUrethra Tissue Engineering
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