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Biocompatible Hydrophilic Modifications of Poly(dimethylsiloxane) Using Self-Assembled Hydrophobins
journal contribution
posted on 2007-06-26, 00:00 authored by Rui Wang, Yan-Lian Yang, Ming Qin, Li-Kai Wang, Lei Yu, Bin Shao, Ming-Qiang Qiao, Chen Wang, Xi-Zeng FengWettability improvement and bioactive interface designing of poly(dimethylsiloxane) (PDMS) are keen
for its application in biodevices. Herein we developed a fully biocompatible approach for achieving
stable hydrophilic surfaces by modifying PDMS with hydrophobins. X-ray photoelectron spectroscopy
(XPS), water contact angle (WCA), and the force curve measurements demonstrated the conversion of
the surface properties from hydrophobic to hydrophilic. The patterning of antigen molecules and the
following immunoassays illustrated that this method should be a feasible strategy for bioactive surface
modification in biosensing devices.