BF3·OEt2‑AgSCF3 Mediated Trifluoromethylthiolation/Cascade Cyclization of Propynols: Synthesis of 4‑((Trifluoromethyl)thio)‑2H‑chromene and 4‑((Trifluoromethyl)thio)-1,2-dihydroquinoline Derivatives
2016-03-14T18:04:03Z (GMT) by
A BF3·OEt2–AgSCF3 mediated direct trifluoromethylthiolation/cascade cyclization of propynols involving the SCF3 anion nucleophilic pathway is developed. This protocol also provides an opportunity to construct valuable trifluoromethylthio-substituted 2H-chromene and 1,2-dihydroquinoline systems with high efficiency under mild conditions. Additionally, the developed BF3·OEt2–AgSCF3 reaction system could be scaled up to gram quantities in a satisfactory yield without inert gas protection.