jf8b05628_si_003.cif (738.15 kB)
Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus Penicillium sclerotiorum cib-411
dataset
posted on 2019-01-31, 00:00 authored by Jia-Lin Tang, Zong-Yuan Zhou, Tao Yang, Can Yao, Lin-Wei Wu, Guo-You LiNine new azaphilone alkaloids, penazaphilones
A–I (1–9), were isolated from
the solid fermented
rice culture of Penicillium sclerotiorum cib-411.
The structures of compounds 1–9 were
elucidated based on HRESIMS, NMR, and CD spectroscopic data. The structures
of 5 and 8 were confirmed by X-ray crystallographic
analyses. Biological evaluation showed that compounds 1, 5, 6, and 8 inhibited the
production of nitric oxide (NO) on RAW 264.7 cells stimulated by lipopolysaccharide
with IC50 values of 15.29, 9.34, 9.50, and 7.05 μM,
respectively. Meanwhile, they did not exhibit obvious cytotoxicity
at a concentration of 50.0 μM.
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exhibitFungus Penicillium sclerotiorum cib -411nitric oxideconcentrationPenicillium sclerotiorum cib -411.azaphilone alkaloids7.05 μ Mrice cultureIC 50 valuesAnti-inflammatory ActivityX-ray50.0 μ Mcompounds 1penazaphiloneBiological evaluationanalysesRAW 264.7 cellsAzaphilone AlkaloidscytotoxicitylipopolysaccharideNMRHRESIMSCD spectroscopic data
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