American Chemical Society
Browse
ol9b00059_si_001.pdf (1.44 MB)

Asymmetric Transfer Hydrogenation of Heterobicyclic Alkenes with Water as Hydrogen Source

Download (1.44 MB)
journal contribution
posted on 2019-02-12, 14:50 authored by Guoli Shen, Jingchao Chen, Dandan Xu, Xia Zhang, Yongyun Zhou, Baomin Fan
The asymmetric transfer hydrogenation of heterobicyclic alkenes was accomplished by using water as the sole hydrogen source. The transformation was co-catalyzed by Pd­(OAc)2/Zn­(OTf)2 dual catalyst with metallic zinc as reducing agent. Various azabenzonorbornadienes and oxabenzonorbornadienes were transformed to the corresponding chiral 1,2-dihydronaphthalenes by the asymmetric reductive ring-opening reactions with good to excellent enantioselectivities.

History