ol800494r_si_001.pdf (1.35 MB)
Asymmetric Transfer Hydrogenation of β,γ-Alkynyl α-Imino Esters by a Brønsted Acid
journal contribution
posted on 2008-05-15, 00:00 authored by Qiang Kang, Zhuo-An Zhao, Shu-Li YouAsymmetric synthesis of trans-alkenyl α-amino esters was realized by chiral phosphoric acid catalyzed transfer hydrogenation of β,γ-alkynyl α-imino esters. Utilizing Hantzsch esters as the hydrogen donor, both the alkyne and imine moieties of β,γ-alkynyl α-imino esters were reduced to afford trans-alkenyl α-amino esters with up to 96% ee.