Asymmetric Synthesis of (−)-Swainsonine

We report a new asymmetric synthetic method for (−)-swainsonine utilizing a chiral oxazoline precursor. The key features in this strategy are the diastereoselective oxazoline formation reaction catalyzed by palladium(0), diasteroselective dihydroxylation, and the stereocontrolled allylation reaction with TiCl<sub>4</sub>.