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Asymmetric Synthesis of (+)-Isofebrifugine and (−)-Sedacryptine from a Common Chiral Nonracemic Building Block

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journal contribution
posted on 2008-09-04, 00:00 authored by Andrew G. H. Wee, Gao-Jun Fan
The stereoselective syntheses of 2-substituted and 2,6-disubstituted 3-hydroxypiperidine alkaloids, (+)-isofebrifugine and (−)-sedacryptine, from a common, functionalized nonracemic bicyclic building block are achieved, demonstrating the flexibilty of the approach.

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