ol9b03356_si_001.pdf (3.39 MB)
Asymmetric Synthesis of γ‑Amino Alcohols by Copper-Catalyzed Hydroamination
journal contribution
posted on 2019-10-17, 21:29 authored by Saki Ichikawa, Stephen L. BuchwaldAsymmetric
synthesis of γ-amino alcohols from unprotected
allylic alcohols by a copper-catalyzed hydroamination strategy has
been developed. Using easily accessible starting materials, a range
of chiral 1,3-amino alcohols were prepared with excellent regio- and
enantioselectivity. Further, this protocol provided an efficient one-step
method for the enantioselective synthesis of γ-amino alcohols
in an intermolecular manner.