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Asymmetric Synthesis of γ‑Amino Alcohols by Copper-Catalyzed Hydroamination

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journal contribution
posted on 2019-10-17, 21:29 authored by Saki Ichikawa, Stephen L. Buchwald
Asymmetric synthesis of γ-amino alcohols from unprotected allylic alcohols by a copper-catalyzed hydroamination strategy has been developed. Using easily accessible starting materials, a range of chiral 1,3-amino alcohols were prepared with excellent regio- and enantioselectivity. Further, this protocol provided an efficient one-step method for the enantioselective synthesis of γ-amino alcohols in an intermolecular manner.

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