Asymmetric α‑Sulfonyl-
and α‑Phosphoryl-Oxylation
of Ketones by a Chiral Hypervalent Iodine(III)

Levitre, Guillaume; Dumoulin, Audrey; Retailleau, Pascal; Panossian, Armen; Leroux, Frédéric R.; Masson, Géraldine

doi:10.1021/acs.joc.7b01597.s001

jo7b01597_si_001.pdf (3.73 MB)

Asymmetric α‑Sulfonyl- and α‑Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III)

journal contribution

posted on 2017-07-21, 00:00 authored by Guillaume Levitre, Audrey Dumoulin, Pascal Retailleau, Armen Panossian, Frédéric R. Leroux, Géraldine Masson

An enantioselective direct oxygenation of propiophenone derivatives mediated by a catalytic or stoichiometric amount of new chiral non-C2-symmetric iodoarenes(III) is reported. The reaction gives an easy entry to optically active α-sulfonyl- and α-phosphoryl oxyketones in respectable yields and enantioselectivities.