Asymmetric Silaboration of Terminal Allenes Bearing α-Stereogenic Centers:  Stereoselection Based on “Reagent Control”

2006-06-08T00:00:00Z (GMT) by Toshimichi Ohmura Michinori Suginome
A highly enantioface-selective silaboration of allenes having stereogenic centers at the α-positions of the double bonds has been achieved using a combination of a chiral silylborane (−)-<b>2</b> and a chiral Pd/(<i>R</i>)-<b>3</b> catalyst. The chiral reagent system efficiently controlled the stereochemistry of the new stereogenic centers even in the reactions of mismatched combinations.