Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

Richmond, Edward; Duguet, Nicolas; M. Z. Slawin, Alexandra; Lébl, Tomáš; Smith, Andrew D.

doi:10.1021/ol300982f.s001

ol300982f_si_001.pdf (7.4 MB)

Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

journal contribution

posted on 2012-06-01, 00:00 authored by Edward Richmond, Nicolas Duguet, Alexandra M. Z. Slawin, Tomáš Lébl, Andrew D. Smith

The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90–99% ee) via a pericyclic cascade process.

Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

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