Asymmetric Palladium-Catalyzed C–H Functionalization Cascade for Synthesis of Chiral 3,4-Dihydroisoquinolones

A palladium-catalyzed C–H functionalization/intramolecular asymmetric allylation cascade of N-sulfonyl benzamides with 1,3-dienes has been developed. In the presence of a chiral pyridine–oxazoline ligand, this protocol enables the synthesis of chiral 3,4-dihydroisoquinolones in yields of up to 83% with enantioselectivities of up to 96%, using environmentally friendly air as the terminal oxidant.