Asymmetric Hydrogenation of Ketones Catalyzed by Ruthenium Hydride Complexes of a Beta-aminophosphine Ligand Derived from Norephedrine
2004-11-08T00:00:00Z (GMT) by
A series ruthenium complexes with the chiral P−N ligand (1R,2R)-PPh2CHPhCHMeNH2 derived from (1S,2R)-norephedrine are synthesized starting from the complexes RuHCl(PPh3)3 or RuHCl(P−P)(PPh3) (P−P= (R)-binap or (S)-binap). These are precatalysts for the efficient asymmetric hydrogenation of simple ketones. For the hydrogenation of acetophenone to 1-phenylethanol, the enantioselectivity observed can be related to the structure of the precatalysts determined by X-ray diffraction. This relationship breaks down for the hydrogenation of pinacolone.
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