Asymmetric Dearomatization of Naphthols via a Rh-Catalyzed C(sp<sup>2</sup>)–H Functionalization/Annulation Reaction
2015-04-22T00:00:00Z (GMT)
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A Rh-catalyzed enantioselective dearomatization
of 1-aryl-2-naphthols with internal alkynes via C–H functionalization
reaction was achieved. In the presence of a chiral Cp/Rh catalyst
and combined oxidants of Cu(OAc)<sub>2</sub> and air (oxygen), various
highly enantioenriched spirocyclic enones bearing an all-carbon quaternary
stereogenic center could be synthesized in 33–98% yields with
up to 97:3 er.
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