la4043638_si_001.pdf (1.26 MB)
Assembly of an Injectable Noncytotoxic Peptide-Based Hydrogelator for Sustained Release of Drugs
journal contribution
posted on 2014-01-28, 00:00 authored by Abhishek Baral, Subhasish Roy, Ashkan Dehsorkhi, Ian W. Hamley, Saswat Mohapatra, Surajit Ghosh, Arindam BanerjeeA new synthetic tripeptide-based
hydrogel has been discovered at
physiological pH and temperature. This hydrogel has been thoroughly
characterized using different techniques including field emission
scanning electron microscopic (FE-SEM) and high-resolution transmission
electron microscopic (HR-TEM) imaging, small- and wide-angle X-ray
diffraction analyses, FT-IR, circular dichroism, and rheometric analyses.
Moreover, this gel exhibits thixotropy and injectability. This hydrogel
has been used for entrapment and sustained release of an antibiotic
vancomycin and vitamin B12 at physiological pH and temperature
for about 2 days. Interestingly, MTT assay of these gelator molecules
shows almost 100% cell viability of this peptide gelator, indicating
its noncytotoxicity.