np6b00013_si_001.pdf (1.69 MB)
Asnovolins A–G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E
journal contribution
posted on 2016-09-14, 12:34 authored by Kazuki Ishikawa, Fumiaki Sato, Takeshi Itabashi, Hiroshi Wachi, Hisashi Takeda, Daigo Wakana, Takashi Yaguchi, Ken-ichi Kawai, Tomoo HosoeSeven novel spiromeroterpenoids,
asnovolins A–G (1–7), one
of which was shown to suppress fibronectin expression, were isolated
from Aspergillus novofumigatus CBS117520 along with
a known compound, novofumigatonin (8). The structures
of asnovolins A–G were elucidated using MS and 2D-NMR data.
Asnovolin E (5) suppressed fibronectin expression by
normal human neonatal dermal fibroblast cells.
