np7b00176_si_001.pdf (8.36 MB)
Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089
journal contribution
posted on 2017-05-10, 16:13 authored by Chun Gui, Shanwen Zhang, Xiangcheng Zhu, Wenjuan Ding, Hongbo Huang, Yu-Cheng Gu, Yanwen Duan, Jianhua JuTwo new spirotetronate aglycones,
22-dehydroxymethyl-kijanolide
(1) and 8-hydroxy-22-dehydroxymethyl-kijanolide (2), along
with seven new spirotetronate glycosides, microsporanates A–F
(3–8) and tetrocarcin P (9), together with three known tetrocarcins [tetrocarcins A (10), B (11), and AC6H (12)], were
isolated from fermentation broths of the marine-derived Micromonospora
harpali SCSIO GJ089. The structures of 1–9 were elucidated on the basis of 1D and 2D NMR and MS spectroscopic
data. Compounds 3–8 feature an α,β-unsaturated
carbonyl moiety within their spirotetronate skeletons. Moreover, compounds 3–12 displayed strong to moderate antibacterial
activities against Gram positive bacteria Bacillus thuringiensis BT01 and B. subtilis BS01 with MIC values
ranging from 0.016 to 8.0 μg/mL.
History
Usage metrics
Categories
Keywords
spirotetronate glycosidesB . subtilis BS 01bacteria BacillusAntimicrobial Spirotetronate Metabolitescarbonyl moietyspirotetronate skeletons. subtiliBT 01MS spectroscopic data2 D NMRMarine-Derived Micromonospora harpali SCSIO GJ 0891 D8- hydroxy -22-dehydroxymarine-derived Micromonospora harpali SCSIO GJ 089.AC 6Hspirotetronate aglyconestetrocarcin PMIC values
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC