np9b00305_si_006.cif (497.32 kB)
Antimicrobial Dolabellanes and Atranones from a Marine-Derived Strain of the Toxigenic Fungus Stachybotrys chartarum
dataset
posted on 2019-07-02, 17:37 authored by Beiye Yang, Yan He, Shuang Lin, Jinwen Zhang, Huaqiang Li, Jianping Wang, Zhengxi Hu, Yonghui ZhangThree new dolabellane-type diterpenoids
(1–3) and three new atranones (4–6) were isolated
and identified from a marine-derived strain of the toxigenic fungus Stachybotrys chartarum. The planar and relative structures
of 1–6 were elucidated using extensive
spectroscopic methods, and their absolute configurations were fully
confirmed via single-crystal X-ray diffraction analysis. Structurally,
compounds 2 and 3 have a 1,14-seco dolabellane-type diterpenoid skeleton; compound 4 is
the first C23 atranone featuring a propan-2-one motif linked
to a dolabellane-type diterpenoid by a carbon–carbon bond;
compound 5 represents the first example of a C24 atranone with a 2-methyltetrahydrofuran-3-carboxylate motif fused
to a dolabellane-type diterpenoid at C-5–C-6. In an in vitro
antimicrobial activity assay, compound 2 was active against Acinetobacter baumannii and Enterococcus faecalis with MIC values of 16 and 32 μg/mL, respectively, while compound 4 exhibited significant inhibitory activities against Candida albicans, Enterococcus faecalis, and methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 8, 16, and 32 μg/mL, respectively.
History
Usage metrics
Categories
Keywords
methicillin-resistant Staphylococcus aureuscompound 42- methyltetrahydrofuran -3-carboxylate motifpropan -2-one motifantimicrobial activity assaytoxigenic fungus Stachybotrys chartarumC 23 atranoneToxigenic Fungus Stachybotrys chartarumC 24 atranoneMRSAEnterococcus faecalisdolabellane-type diterpenoidsingle-crystal X-ray diffraction analysisMIC values
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC