np020099i_si_001.pdf (144.18 kB)
Antiemetic Principles of Alpinia officinarum
journal contribution
posted on 2002-07-16, 00:00 authored by Daitetsu Shin, Kaoru Kinoshita, Kiyotaka Koyama, Kunio TakahashiBioasay-guided fractionation of the antiemetic constituents of Alpinia officinarum was performed, and
eight compounds (1−8) including a new compound were isolated. Among the seven known compounds,
two flavonoids (1, 2), four diarylheptanoids (3, 5, 6, 8), and one sterol (4) were obtained, with five (2−6)
of those compounds showing antiemetic activity in a copper sulfate induced emesis assay in young chicks.
The structure of the new compound 7, which also showed antiemetic activity, was determined as 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-3-heptanone. The structure of 7 was established on
the basis of spectroscopic data interpretation.