An Improved Procedure for Preparation of Carbapenem Antibiotic:  Meropenem

Tewari, Neera; Nizar, Hashim; Rai, Bishwa Prakash; Singh, Shailendra K.; George, Vinod; Prasad, Mohan

doi:10.1021/op700088y.s002

op700088y_si_002.pdf (56.21 kB)

An Improved Procedure for Preparation of Carbapenem Antibiotic: Meropenem

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posted on 2007-07-20, 00:00 authored by Neera Tewari, Hashim Nizar, Bishwa Prakash Rai, Shailendra K. Singh, Vinod George, Mohan Prasad

An efficient synthesis of a 1β-methyl carbapenem antibiotic, meropenem, is described. The present process does not involve cryogenic temperatures, chromatographic purification, or reverse osmosis and is amenable to large scale synthesis.

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Keywords

antibiotic carbapenem purification scale synthesis methyl osmosi cryogenic temperatures Meropenem Preparation Procedure Antibiotic meropenem Carbapenem

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