ol049921v_si_001.pdf (301.26 kB)
An Efficient Synthesis of 3-Substituted 3H-Pyrimidin-4-ones
journal contribution
posted on 2004-03-18, 00:00 authored by Jae Uk Jeong, Xiaohong Chen, Attiq Rahman, Dennis S. Yamashita, Juan I. LuengoA novel and practical synthesis of 3-substituted 3H-pyrimidin-4-ones is described. The key step involves the cyclization of enamide esters,
derived from readily available β-keto esters, with trimethylaluminum and various primary amines.