An Efficient Synthesis of 3-Substituted
3H-Pyrimidin-4-ones

Jeong, Jae Uk; Chen, Xiaohong; Rahman, Attiq; Yamashita, Dennis S.; Luengo, Juan I.

doi:10.1021/ol049921v.s001

ol049921v_si_001.pdf (301.26 kB)

An Efficient Synthesis of 3-Substituted 3H-Pyrimidin-4-ones

journal contribution

posted on 2004-03-18, 00:00 authored by Jae Uk Jeong, Xiaohong Chen, Attiq Rahman, Dennis S. Yamashita, Juan I. Luengo

A novel and practical synthesis of 3-substituted 3H-pyrimidin-4-ones is described. The key step involves the cyclization of enamide esters, derived from readily available β-keto esters, with trimethylaluminum and various primary amines.

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Keywords

cyclization Efficient Synthesis Substituted trimethylaluminum synthesis Pyrimidin pyrimidin amines keto 3 H enamide esters

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CC BY-NC 4.0

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